3-氧代-5BETA-胆酸
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- CAS号:
- 1553-56-6
- 英文名:
- 3-Oxo-5beta-cholanoic Acid
- 英文别名:
- 3-oxocholanicacid;3-KETOCHOLANIC ACID;3-oxolithocholicacid;3-ketolithocholicacid;3-Oxo-5β-cholanic acid;5β-CHOLANIC acid-3-ONE;3-oxocholan-24-oic acid;5-B-CHOLANIC ACID-3-ONE;5β-Cholanic acid-3-one;3-Oxo-5β-cholanoic Acid
- 中文名:
- 3-氧代-5BETA-胆酸
- 中文别名:
- -胆烷酸;脱氢石胆酸;3-氧代-5&Β;3-氧-5Β-胆酸;熊去氧胆酸杂质60;3-酮-5B-胆烷酸;化合物 T13502;3-氧代-5Β-胆酸;3-氧代-5Β-胆烷酸;3-氧代-5&BETA
- CBNumber:
- CB0675020
- 分子式:
- C24H38O3
- 分子量:
- 374.56
- MOL File:
- 1553-56-6.mol
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3-氧代-5BETA-胆酸化学性质
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熔点:
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140-141 °C
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沸点:
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509.3±23.0 °C(Predicted)
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密度:
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1.069±0.06 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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4.76±0.10(Predicted)
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颜色:
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White to Pale Yellow
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CAS 数据库:
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1553-56-6
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3-氧代-5BETA-胆酸性质、用途与生产工艺
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，胆汁酸代谢产物，通过直接与关键转录因子RORγt (Kd=1.13 μM) 结合抑制 TH17 细胞分化。
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
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Animal Model:
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B6 Jax mice (with a faecal slurry containing SFB)
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Dosage:
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0.3% (w/w)
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Administration:
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Gavaged; for 1 week
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Result:
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Significantly reduced the percentage of ileal TH17 cells.
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3-氧代-5BETA-胆酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-125801 | 3-Oxo-5β-cholanoic acid | | 1 mg | 156元 |
| 2024/11/08 | HY-125801 | 3-Oxo-5β-cholanoic acid | | 5 mg | 312元 |
1553-56-6, 3-氧代-5BETA-胆酸 相关搜索:
- 杂质对照品
- 抑制剂
- 药靶配体
- 3-氧代-5Β-胆烷酸标准品
- (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13--二甲基-3-氧代十六氢-1H-环戊并[A]菲17-基)戊酸
- 熊去氧胆酸杂质60
- 3-氧-5Β-胆酸
- 3-酮-5B-胆烷酸(脱氢石胆酸)
- 3-酮-5B-胆烷酸
- 化合物 T13502
- 3-氧代-5Β-胆酸
- 3-恶唑烷-24-油酸
- 3-氧代-5BETA-胆酸
- 脱氢石胆酸
- 3-氧代-5Β-胆烷酸
- 3-氧代-5&BETA
- 3-氧代-5&Β
- -胆烷酸
- 1553-56-6
- (R)-4-((5R,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
- Ursodeoxycholic acid impurity 60
- Cholan-24-oic acid, 3-oxo-, (5β)-
- cell,factor,RAR-related orphan receptor,3 Oxo 5β cholanoic acid,TH17,RORγt,differentiation,acid,bile,Inhibitor,responses,transcription,inhibit,ROR,3Oxo5βcholanoic acid,immune,3-oxoLCA
- 3-Oxo-5β-cholanoic Acid
- 5β-CHOLANIC acid-3-ONE
- 3-Oxo-5beta-cholanoic Acid
- DEHYDROLITHOCHOLIC ACID
- 3-oxo-5beta-cholanic acid
- 3-Keto-5β-cholanic acid
- 3-Oxo-5β-cholanoic Acid
- 3-Oxo-5β-cholanic acid
- 3-Oxo-5β-cholan-24-oic acid
- 5β-Cholanic acid-3-one
- 3-Keto-5β-cholanic acid, Dehydrolithocholic acid
- 3-oxocholan-24-oic acid
- 5-B-CHOLANIC ACID-3-ONE
- 3-oxolithocholicacid
- 3-oxocholanicacid
- 3-oxo-5-beta-cholan-24-oicacid
- 3-oxo-5-beta-cholan-24-oicaci
- 3-ketolithocholicacid
- (5-beta)-cholan-24-oicaci
- 3-KETO-5BETA-CHOLANIC ACID
- 3-KETOCHOLANIC ACID
- 5BETA-CHOLANIC ACID-3-ONE