-胆烷酸
| 中文名称 | -胆烷酸 |
|---|---|
| 中文同义词 | -胆烷酸;3-氧代-5&Β;3-氧代-5Β3-氧代-5Β-胆烷酸;脱氢石胆酸;3-氧代-5BETA-胆酸;3-恶唑烷-24-油酸;3-氧代-5Β-胆酸 |
| 英文名称 | 3-Oxo-5beta-cholanoic Acid |
| 英文同义词 | 5BETA-CHOLANIC ACID-3-ONE;3-KETOCHOLANIC ACID;3-KETO-5BETA-CHOLANIC ACID;(5-beta)-cholan-24-oicaci;3-ketolithocholicacid;3-oxo-5-beta-cholan-24-oicaci;3-oxo-5-beta-cholan-24-oicacid;3-oxocholanicacid |
| CAS号 | 1553-56-6 |
| 分子式 | C24H38O3 |
| 分子量 | 374.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1553-56-6.mol |
| 结构式 |  |
-胆烷酸 性质
| 熔点 | 140-141 °C |
|---|---|
| 沸点 | 509.3±23.0 °C(Predicted) |
| 密度 | 1.069±0.06 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
| 颜色 | 白色至浅黄色 |
| CAS 数据库 | 1553-56-6 |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，胆汁酸代谢产物，通过直接与关键转录因子RORγt (Kd=1.13 μM) 结合抑制 TH17 细胞分化。
Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.
| Animal Model: | B6 Jax mice (with a faecal slurry containing SFB) |
| Dosage: | 0.3% (w/w) |
| Administration: | Gavaged; for 1 week |
| Result: | Significantly reduced the percentage of ileal TH17 cells. |
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | FZ2281400 |
| 海关编码 | 2918.30.9000 |
| 提供商 | 语言 |
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英文
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