N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
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- CAS号:
- 53671-71-9
- 英文名:
- ICI 89406
- 英文别名:
- C025716;ICI 89406;N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA;1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea;Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-;Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
- 中文名:
- N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
- 中文别名:
- 化合物ICI 89406;N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
- CBNumber:
- CB0741961
- 分子式:
- C19H22N4O3
- 分子量:
- 354.4
- MOL File:
- 53671-71-9.mol
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N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲化学性质
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熔点:
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155-156 °C(Solv: acetonitrile (75-05-8))
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沸点:
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575.0±50.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble in ethanol and to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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12.29±0.46(Predicted)
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颜色:
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White to off-white
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N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲性质、用途与生产工艺
ICI 89406 是选择性的 β1 肾上腺素能受体 (β1 adrenergic receptor) 的拮抗剂,适用于 PET 用正电子发射器标记。
Animal Model:
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Rats.
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Dosage:
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0.6, 5 or 50 mg/kg.
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Administration:
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Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
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Result:
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Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
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N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-15726 | ICI 89406 | | 1 mg | 1049元 |
N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
生产厂家
53671-71-9, N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲 相关搜索:
- 化合物ICI 89406
- N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
- 53671-71-9
- Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
- 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea
- Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-
- C025716
- ICI 89406
- N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA