N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲
| 中文名称 | N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲 |
|---|---|
| 中文同义词 | N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲;化合物ICI 89406 |
| 英文名称 | ICI 89406 |
| 英文同义词 | N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA;ICI 89406;C025716;Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-;1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea;Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406 |
| CAS号 | 53671-71-9 |
| 分子式 | C19H22N4O3 |
| 分子量 | 354.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 53671-71-9.mol |
| 结构式 | ![N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲 结构式](CAS/GIF/53671-71-9.gif) |
N-[2-[[3-(2-氰基苯氧基)-2-羟基丙基]氨基]乙基]-N'-苯基脲 性质
| 熔点 | 155-156 °C(Solv: acetonitrile (75-05-8)) |
|---|---|
| 沸点 | 575.0±50.0 °C(Predicted) |
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 可溶于乙醇，在 DMSO 中溶解至 100 mM |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.29±0.46(Predicted) |
| 颜色 | 白色至米白色 |
ICI 89406 是选择性的 β1 肾上腺素能受体 (β1 adrenergic receptor) 的拮抗剂，适用于 PET 用正电子发射器标记。
| Animal Model: | Rats. |
| Dosage: | 0.6, 5 or 50 mg/kg. |
| Administration: | Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis). |
| Result: | Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%. |