NCGC00249987
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- CAS号:
- 1384864-80-5
- 英文名:
- NCGC00249987
- 英文别名:
- NCGC00249987;NCGC00249987,NCGC-00249987;Benzoic acid, 3-fluoro-, 2-[[5-(2-pyrimidinylthio)-2-furanyl]methylene]hydrazide
- 中文名:
- NCGC00249987
- 中文别名:
- 化合物 T12194
- CBNumber:
- CB08054472
- 分子式:
- C16H11FN4O2S
- 分子量:
- 342.35
- MOL File:
- 1384864-80-5.mol
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NCGC00249987化学性质
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密度:
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1.39±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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11.32±0.46(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light yellow
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NCGC00249987性质、用途与生产工艺
NCGC00249987 是一种高度选择性和变构 Eya2 的 Tyr 磷酸酶活性的抑制剂，对 Eya2 ED 和 MBP-Eya2 FL 的 IC50 分别为 3 μM 和 6.9 μM。NCGC00249987 专门针对肺癌细胞的迁移，侵袭伪足形成和侵袭。
IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)
NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members.
NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg
2+
binding, thereby inhibiting Eya2’s Tyr phosphatase activity.
NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival.
NCGC00249987
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-133512 | NCGC00249987 | | 1 mg | 500元 |
| 2024/04/30 | HY-133512 | NCGC00249987
NCGC00249987 | 1384864-80-5 | 5mg | 1150元 |
1384864-80-5, NCGC00249987 相关搜索:
- 化合物 T12194
- 1384864-80-5
- Benzoic acid, 3-fluoro-, 2-[[5-(2-pyrimidinylthio)-2-furanyl]methylene]hydrazide
- NCGC00249987,NCGC-00249987
- NCGC00249987