NCGC00249987
中文名称 | NCGC00249987 |
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中文同义词 | 化合物 T12194;化合物 NCGC00249987 |
英文名称 | NCGC00249987 |
英文同义词 | NCGC00249987;NCGC00249987,NCGC-00249987;Benzoic acid, 3-fluoro-, 2-[[5-(2-pyrimidinylthio)-2-furanyl]methylene]hydrazide |
CAS号 | 1384864-80-5 |
分子式 | C16H11FN4O2S |
分子量 | 342.35 |
EINECS号 | |
相关类别 | |
Mol文件 | 1384864-80-5.mol |
结构式 |
NCGC00249987 性质
密度 | 1.39±0.1 g/cm3(Predicted) |
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酸度系数(pKa) | 11.32±0.46(Predicted) |
形态 | 固体 |
颜色 | 米白色至浅黄色 |
IC50: 3 μM (Eya2 ED) and 6.9 μM (MBP-Eya2 FL)
NCGC00249987 inhibits Eya2 ED (C-terminal Eya Domain). NCGC00249987 inhibits full length Eya2 including but not other Eya family members.
NCGC00249987 binding leads to a conformational change of the active site that is unfavorable for Mg
2+
binding, thereby inhibiting Eya2’s Tyr phosphatase activity.
NCGC00249987 (5, 10 μM) treatment effectively suppresses migration, invadopodia formation and invasion in Eya2 WT expressing Calu-6 cells, but not in EV Calu-6 cells. NCGC00249987 does not inhibit cell growth or survival.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-133512 | NCGC00249987 | 1 mg | 500元 | |
2024/08/19 | HY-133512 | NCGC00249987 NCGC00249987 | 1384864-80-5 | 5mg | 1150元 |