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2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
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- CAS号:
- 105118-14-7
- 英文名:
- Datelliptium
- 英文别名:
- Datelliptium;2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-Pyrido[4,3-b]carbazolium, chloride (1:1)
- 中文名:
- 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
- 中文别名:
- 化合物DATELLIPTIUM CHLORIDE;DATELLIPTIUM CHLORIDE盐酸盐;2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑,氯化物(1:1)
- CBNumber:
- CB11178417
- 分子式:
- 分子量:
- 0
- MOL File:
- 105118-14-7.mol
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2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:5.0(Max Conc. mg/mL);12.56(Max Conc. mM)
H2O:41.67(Max Conc. mg/mL);104.71(Max Conc. mM)-
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形态:
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Solid
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颜色:
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Pink to red
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2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑性质、用途与生产工艺
Datelliptium chloride 是一种源于 ellipticine 的 DNA 嵌合剂，具有抗肿瘤活性。
Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.
2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2023/01/06 | S0180 | 105118-14-7
Datelliptium chloride | 105118-14-7 | 5mg | 20320.5元 |
2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
生产厂家
105118-14-7, 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 相关搜索:
1,9-二甲氧基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 2-[(2-二乙基氨基)乙基]-5,11-二甲基-6H-吡咯[4,3-B]咔唑溴化物半氢溴酸盐 9-甲氧基-5-甲基-6H-吡啶并[4,3-B]咔唑 (+)-11-(2-(2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-6H-吡啶并[2,3-B][1,4]苯二氮杂卓-6-酮 11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-B][1.4]苯并二氮杂-6-酮 3,9-二溴-5,11-双(2-乙基己基)-5,11二氢吲哚[3,2-B]咔唑
- 抑制剂
- 标准品
- 化合物DATELLIPTIUM CHLORIDE
- DATELLIPTIUM CHLORIDE盐酸盐
- 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑,氯化物(1:1)
- 105118-14-7
- 2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-Pyrido[4,3-b]carbazolium, chloride (1:1)
- Datelliptium