2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑
| 中文名称 | 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 |
|---|---|
| 中文同义词 | 2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑,氯化物(1:1);DATELLIPTIUM CHLORIDE盐酸盐;化合物DATELLIPTIUM CHLORIDE |
| 英文名称 | Datelliptium |
| 英文同义词 | Datelliptium;2-[2-(diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-Pyrido[4,3-b]carbazolium, chloride (1:1) |
| CAS号 | 105118-14-7 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 105118-14-7.mol |
| 结构式 | ![2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 结构式](CAS/GIF/105118-14-7.gif) |
2-[2-(二乙氨基)乙基]-9-羟基-5,11-二甲基-6H-吡啶并[4,3-B]咔唑 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:5.0(最大浓度 mg/mL);12.56(最大浓度 mM) H2O:41.67(最大浓度 mg/mL);104.71(最大浓度 mM) |
| 形态 | 固体 |
| 颜色 | 粉红至红色 |
Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/01/06 | S0180 | 105118-14-7 Datelliptium chloride | 105118-14-7 | 5mg | 20320.5元 |