LANICEMINE
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- CAS号:
- 153322-05-5
- 英文名:
- LaniceMine
- 英文别名:
- LaniceMine;(1S)-1-phenyl-2-pyridin-2-ylethanamine;2-PyridineethanaMine, a-phenyl-, (aS)-;2-Pyridineethanamine, α-phenyl-, (αS)-;(S)-1-phenyl-2-(pyridin-2-yl)ethanamine;(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE
- 中文名:
- LANICEMINE
- 中文别名:
- 拉尼西明;化合物 T15706
- CBNumber:
- CB12611425
- 分子式:
- C13H14N2
- 分子量:
- 198.27
- MOL File:
- 153322-05-5.mol
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LANICEMINE化学性质
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沸点:
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307.7±27.0 °C(Predicted)
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密度:
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1.097±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
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形态:
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neat oil
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酸度系数(pKa):
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8.29±0.10(Predicted)
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颜色:
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Colorless to light yellow
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LANICEMINE性质、用途与生产工艺
Lanicemine (AZD6765) 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。
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Cell Line:
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Concentration:
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Incubation Time:
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Result:
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Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects.
Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
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Animal Model:
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Male Sprague-Dawley rats
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Dosage:
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3, 10 or 30 mg/kg
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Administration:
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Intraperitoneal
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Result:
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Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
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LANICEMINE
上下游产品信息
上游原料
下游产品
153322-05-5, LANICEMINE 相关搜索:
- 抑制剂
- 化合物 T15706
- 拉尼西明
- 153322-05-5
- (1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE
- 2-Pyridineethanamine, α-phenyl-, (αS)-
- (S)-1-phenyl-2-(pyridin-2-yl)ethanamine
- (1S)-1-phenyl-2-pyridin-2-ylethanamine
- 2-PyridineethanaMine, a-phenyl-, (aS)-
- LaniceMine