LANICEMINE
| 中文名称 | LANICEMINE |
|---|---|
| 中文同义词 | 拉尼西明;化合物 T15706 |
| 英文名称 | LaniceMine |
| 英文同义词 | LaniceMine;2-PyridineethanaMine, a-phenyl-, (aS)-;(1S)-1-phenyl-2-pyridin-2-ylethanamine;(S)-1-phenyl-2-(pyridin-2-yl)ethanamine;2-Pyridineethanamine, α-phenyl-, (αS)-;(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE |
| CAS号 | 153322-05-5 |
| 分子式 | C13H14N2 |
| 分子量 | 198.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 153322-05-5.mol |
| 结构式 |  |
LANICEMINE 性质
| 沸点 | 307.7±27.0 °C(Predicted) |
|---|---|
| 密度 | 1.097±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇中≤20mg/ml；DMSO 中≤30mg/ml；二甲基甲酰胺中≤5mg/ml |
| 形态 | 油状 |
| 酸度系数(pKa) | 8.29±0.10(Predicted) |
| 颜色 | 无色至浅黄 |
Lanicemine (AZD6765) 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。
NMDA receptor
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| Result: |
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30 mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |