LaniceMine manufacturers
- Lanicemine
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- $50.00 / 1kg
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2024-08-15
- CAS:153322-05-5
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20tons
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| | LaniceMine Basic information |
| Product Name: | LaniceMine | | Synonyms: | LaniceMine;2-PyridineethanaMine, a-phenyl-, (aS)-;(1S)-1-phenyl-2-pyridin-2-ylethanamine;(S)-1-phenyl-2-(pyridin-2-yl)ethanamine;2-Pyridineethanamine, α-phenyl-, (αS)-;(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE | | CAS: | 153322-05-5 | | MF: | C13H14N2 | | MW: | 198.27 | | EINECS: | | | Product Categories: | | | Mol File: | 153322-05-5.mol |  |
| | LaniceMine Chemical Properties |
| Boiling point | 307.7±27.0 °C(Predicted) | | density | 1.097±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide | | form | neat oil | | pka | 8.29±0.10(Predicted) | | color | Colorless to light yellow |
| | LaniceMine Usage And Synthesis |
| Description | Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 μM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity. | | Uses | Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent. | | in vitro | previous study with lanicemine and ketamine found that both compounds could bind with low-to-moderate affinity to sites within the nmda channel pore, exhibit strong voltage dependence, and have similar lack of nr2a vs nr2b subunit selectivity [1]. | | in vivo | in animal study, cortical eeg recordings were obtained from rats trained to perform an auditory detection task for food reward. results showed that both lanicemine and ketamine produced pronounced dose-dependent elevations in spontaneous gamma-band eeg, but only gamma changes for ketamine were tightly coupled to increases in locomotor activity, indicating that lanicemine not only engaged brain circuits involved in the generation of gamma-eeg, but also influenced these networks independent of the broader systemslevel disruptions typical of ketamine [1]. | | IC 50 | 4-7 μm | | references | [1] g. sanacora, m. a. smith, s. pathak, et al. lanicemine: a low-trapping nmda channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. molecular psychiatry 19(9), 978-985 (2014). |
| | LaniceMine Preparation Products And Raw materials |
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