(5Z)-7-OXOZEAENOL
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- CAS号:
- 253863-19-3
- 英文名:
- LL Z1640-2
- 英文别名:
- nol;C 292;L 783279;FR148083;f 152 A1;5Z-7-Oxoze&ÆTAK1 inhibitor 5ZO);5Z-7-Oxozeaenol >=98% (HPLC);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- 中文名:
- (5Z)-7-OXOZEAENOL
- 中文别名:
- (5Z)-7-氧杂烯醇;化合物5Z-7-OXOZEAENOL;5Z-7-OXOZE&ÆLIG;NOL;FR148083|||L783279|||LL-Z 1640-2
- CBNumber:
- CB12744545
- 分子式:
- C19H22O7
- 分子量:
- 362.37
- MOL File:
- 253863-19-3.mol
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(5Z)-7-OXOZEAENOL化学性质
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熔点:
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171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
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沸点:
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666.8±55.0 °C(Predicted)
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密度:
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1.270±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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形态:
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powder
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酸度系数(pKa):
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7.32±0.70(Predicted)
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颜色:
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white to off-white
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(5Z)-7-OXOZEAENOL性质、用途与生产工艺
5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物,为有效的,不可逆的,选择性的 TAK1 和 VEGF-R2 抑制剂,IC50 值分别为 8 nM 和 52 nM。
TAK1
8.1 nM (IC
50
)
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VEGFR-2
52 nM (IC
50
)
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VEGFR-3
110 nM (IC
50
)
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FLT3
170 nM (IC
50
)
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PDGFR-β
340 nM (IC
50
)
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B-RAF VE
6300 nM (IC
50
)
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SRC
6600 nM (IC
50
)
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MEK1
411 nM (IC
50
)
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5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC
50
, 8.1 nM), less active on MEK1 (IC
50
, 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC
50
of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC
50
s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.
(5Z)-7-OXOZEAENOL
上下游产品信息
上游原料
下游产品
253863-19-3, (5Z)-7-OXOZEAENOL 相关搜索:
- 制剂-抑制剂
- 对照品
- 微生物代谢物
- FR148083|||L783279|||LL-Z 1640-2
- 5Z-7-OXOZE&ÆLIG;NOL
- (5Z)-7-氧杂烯醇
- 化合物5Z-7-OXOZEAENOL
- 253863-19-3
- 5Z-7-Oxoze&Æ
- nol
- 5Z-7-Oxozeaenol >=98% (HPLC)
- 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
- TAK1 inhibitor 5ZO)
- (2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
- L 783279
- FR148083
- C 292
- f 152 A1