(5Z)-7-OXOZEAENOL
中文名称 | (5Z)-7-OXOZEAENOL |
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中文同义词 | 化合物5Z-7-OXOZEAENOL;(5Z)-7-氧杂烯醇;5Z-7-OXOZE&ÆLIG;NOL;FR148083|||L783279|||LL-Z 1640-2 |
英文名称 | LL Z1640-2 |
英文同义词 | f 152 A1;C 292;FR148083;L 783279;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;TAK1 inhibitor 5ZO);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;5Z-7-Oxozeaenol >=98% (HPLC) |
CAS号 | 253863-19-3 |
分子式 | C19H22O7 |
分子量 | 362.37 |
EINECS号 | |
相关类别 | 微生物代谢物;对照品;制剂-抑制剂 |
Mol文件 | 253863-19-3.mol |
结构式 | ![]() |
(5Z)-7-OXOZEAENOL 性质
熔点 | 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) |
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沸点 | 666.8±55.0 °C(Predicted) |
密度 | 1.270±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:>10mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 7.32±0.70(Predicted) |
颜色 | 白色至类白色 |
TAK1 8.1 nM (IC 50 ) |
VEGFR-2 52 nM (IC 50 ) |
VEGFR-3 110 nM (IC 50 ) |
FLT3 170 nM (IC 50 ) |
PDGFR-β 340 nM (IC 50 ) |
B-RAF VE 6300 nM (IC 50 ) |
SRC 6600 nM (IC 50 ) |
MEK1 411 nM (IC 50 ) |
5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC 50 , 8.1 nM), less active on MEK1 (IC 50 , 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC 50 of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC 50 s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.