DEFORMYLFLUSTRABROMINE HYDROCHLORIDE
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- CAS号:
- 951322-11-5
- 英文名:
- dFBr hydrochloride
- 英文别名:
- dFBr hydrochloride;Deformylflustrabromine hydrochloride;6-Bromo-2-(1,1-dimethyl-2-propen-1-yl)-N-methyl-1H-indole-3-ethanamine hydrochloride
- 中文名:
- DEFORMYLFLUSTRABROMINE HYDROCHLORIDE
- 中文别名:
- 化合物 T11004
- CBNumber:
- CB12750661
- 分子式:
- C16H22BrClN2
- 分子量:
- 357.72
- MOL File:
- 951322-11-5.mol
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DEFORMYLFLUSTRABROMINE HYDROCHLORIDE化学性质
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熔点:
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211-214 °C
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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powder
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颜色:
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white to beige
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DEFORMYLFLUSTRABROMINE HYDROCHLORIDE性质、用途与生产工艺
Desformylflustrabromine hydrochloride 是一个有选择性的 α4β2 神经元烟碱乙酰胆碱受体 (nAChR) 激动剂，其 pEC50 值为 6.48。
Desformylflustrabromine hydrochloride is a selective agonist of α
4
β
2
neuronal nicotinic acetylcholine receptor (nAChR) with a pEC
50
of 6.48. ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC
50
=6.4±0.2) compare with the HS isoform (pEC
50
=5.6±0.2). Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).
DEFORMYLFLUSTRABROMINE HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
DEFORMYLFLUSTRABROMINE HYDROCHLORIDE
生产厂家
951322-11-5, DEFORMYLFLUSTRABROMINE HYDROCHLORIDE 相关搜索:
- C16H21BrN2ClH
- 化合物 T11004
- 951322-11-5
- 6-Bromo-2-(1,1-dimethyl-2-propen-1-yl)-N-methyl-1H-indole-3-ethanamine hydrochloride
- dFBr hydrochloride
- Deformylflustrabromine hydrochloride