DEFORMYLFLUSTRABROMINE HYDROCHLORIDE
| 中文名称 | DEFORMYLFLUSTRABROMINE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T11004 |
| 英文名称 | dFBr hydrochloride |
| 英文同义词 | Deformylflustrabromine hydrochloride;dFBr hydrochloride;6-Bromo-2-(1,1-dimethyl-2-propen-1-yl)-N-methyl-1H-indole-3-ethanamine hydrochloride |
| CAS号 | 951322-11-5 |
| 分子式 | C16H22BrClN2 |
| 分子量 | 357.72 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 951322-11-5.mol |
| 结构式 |  |
DEFORMYLFLUSTRABROMINE HYDROCHLORIDE 性质
| 熔点 | 211-214 °C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
α 4 β 2 nAChR
Desformylflustrabromine hydrochloride is a selective agonist of α 4 β 2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC 50 of 6.48. ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC 50 =6.4±0.2) compare with the HS isoform (pEC 50 =5.6±0.2). Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).
安全信息
| WGK Germany | 3 |
|---|