1638241-89-0
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- CAS号:
- 1638241-89-0
- 英文名:
- STING-Inducer-1
- 英文别名:
- MIW815;ML RR-S2 CDA;STING-Inducer-1;ML RR-S2 CDA(MIW815;ADUS100,ADU S100,ADU-S-100;ML RR-S2 CDA;MIW815;STING-INDUCER-1;ML RR-S2 CDA;STING-INDUCER-1;1638241-89-0;Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide
- 中文名:
- 1638241-89-0
- 中文别名:
- 化合物 T10252L3;MIW815; ML RR-S2 CDA
- CBNumber:
- CB13041465
- 分子式:
- C20H24N10O10P2S2
- 分子量:
- 690.54
- MOL File:
- 1638241-89-0.mol
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1638241-89-0化学性质
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沸点:
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1020.8±75.0 °C(Predicted)
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密度:
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2.43±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 2 mg/mL (2.90 mM)
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形态:
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Solid
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酸度系数(pKa):
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-0.67±0.70(Predicted)
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颜色:
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White to off-white
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InChIKey:
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IZJJFUQKKZFVLH-UUXHIKLWNA-N
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1638241-89-0性质、用途与生产工艺
ADU-S100 (MIW815) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING
REF
and hSTING
Q
alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8
+
T cell responses, and improves long-term survival to 50%.
1638241-89-0
上下游产品信息
上游原料
下游产品
1638241-89-0, 1638241-89-0 相关搜索:
- DNA单体
- C20H24N10O10P2S2
- MIW815; ML RR-S2 CDA
- 化合物 T10252L3
- 1638241-89-0
- ML RR-S2 CDA(MIW815
- ADUS100,ADU S100,ADU-S-100
- MIW815
- ML RR-S2 CDA;MIW815;STING-INDUCER-1
- ML RR-S2 CDA;STING-INDUCER-1;1638241-89-0
- Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide
- ML RR-S2 CDA
- STING-Inducer-1