1638241-89-0
| 中文名称 | 1638241-89-0 |
|---|---|
| 中文同义词 | 化合物 T10252L3;MIW815; ML RR-S2 CDA |
| 英文名称 | STING-Inducer-1 |
| 英文同义词 | STING-Inducer-1;ML RR-S2 CDA;Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide;ML RR-S2 CDA;STING-INDUCER-1;1638241-89-0;ML RR-S2 CDA;MIW815;STING-INDUCER-1;MIW815;ADUS100,ADU S100,ADU-S-100;ML RR-S2 CDA(MIW815 |
| CAS号 | 1638241-89-0 |
| 分子式 | C20H24N10O10P2S2 |
| 分子量 | 690.54 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1638241-89-0.mol |
| 结构式 |  |
1638241-89-0 性质
| 沸点 | 1020.8±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.43±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：2 mg/mL（2.90 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | -0.67±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| InChIKey | IZJJFUQKKZFVLH-UUXHIKLWNA-N |
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.