2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
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- CAS号:
- 729589-58-6
- 英文名:
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 英文别名:
- 2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
- 中文名:
- 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 中文别名:
- 2-FUROYL-LIGRLO-酰胺 三氟乙酸盐;呋喃甲酸-亮氨酸-异亮氨酸-甘氨酸-精氨酸-亮氨酸-鸟氨酸-NH2;N-(2-呋喃基羰基)-L-亮氨酰-L-异亮氨酰甘氨酰-L-精氨酰基-L-亮氨酰-L-鸟氨酸酰胺
- CBNumber:
- CB1382037
- 分子式:
- C36H63N11O8
- 分子量:
- 777.95
- MOL File:
- 729589-58-6.mol
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2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2化学性质
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in H2O
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形态:
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powder
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酸度系数(pKa):
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12.91±0.46(Predicted)
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颜色:
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white
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水溶解性:
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Soluble to 1 mg/ml in water
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2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2性质、用途与生产工艺
2-Furoyl-LIGRLO-amide 是一种有效的选择性蛋白酶激活受体2 (PAR2) 激动剂, 其 pD2 值为 7.0。
Proteinase-activated receptor 2 (PAR2)
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is equally effective to and 10 to 25 times more potent than SLIGRLNH
2
for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively.
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is 10 to 300 times more potent than SLIGRL-NH
2
. Unlike trans-cinnamoyl-LIGRLO-NH
2
, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.
Furoyl-LIGRLO-amide (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3
-/-
mice. But it decreases significantly the number of scratches in WT mice.
Animal Model:
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Adult male (2/3-month-old) Trpv3
-/-
and WT mice
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Dosage:
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10 μg
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Administration:
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Injected intradermally at the nape of the neck
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Result:
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Was involved in PAR2- induced acute itch.
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2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-P1314 | 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-Furoyl-LIGRLO-amide | 729589-58-6 | 1mg | 1200元 |
2024/04/30 | HY-P1314 | 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-Furoyl-LIGRLO-amide | 729589-58-6 | 5mg | 3600元 |
2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
生产厂家
729589-58-6, 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 相关搜索:
- 药靶配体
- 目录肽
- 标准品
- 多肽
- C36H63N11O8
- 2-FUROYL-LIGRLO-酰胺 三氟乙酸盐
- 呋喃甲酸-亮氨酸-异亮氨酸-甘氨酸-精氨酸-亮氨酸-鸟氨酸-NH2
- N-(2-呋喃基羰基)-L-亮氨酰-L-异亮氨酰甘氨酰-L-精氨酰基-L-亮氨酰-L-鸟氨酸酰胺
- 729589-58-6
- Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist
- 2-Furoyl-LIGRLO-NH2
- 2-Furoyl-LIGRLO-amid
- N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide
- L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-
- 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist
- f-LIGRLO-NH2
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt
- 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt
- 2-Fly
- 2-f-LIGRLO-NH2
- 2fLI
- (2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat)
- 2-FUROYL-LIGRLO-AMIDE
- 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 2F-LIGRLO-AMIDE
- 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT)
- 2-(2-FUROYL)-LIGRLOAMIDE
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II
- PAR-2 AGONIST II