2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
| 中文名称 | 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 |
|---|---|
| 中文同义词 | N-(2-呋喃基羰基)-L-亮氨酰-L-异亮氨酰甘氨酰-L-精氨酰基-L-亮氨酰-L-鸟氨酸酰胺;呋喃甲酸-亮氨酸-异亮氨酸-甘氨酸-精氨酸-亮氨酸-鸟氨酸-NH2;2-FUROYL-LIGRLO-酰胺 三氟乙酸盐 |
| 英文名称 | 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 |
| 英文同义词 | PAR-2 AGONIST II;PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II;2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2;2-(2-FUROYL)-LIGRLOAMIDE;2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT);2F-LIGRLO-AMIDE;2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2;2-FUROYL-LIGRLO-AMIDE |
| CAS号 | 729589-58-6 |
| 分子式 | C36H63N11O8 |
| 分子量 | 777.95 |
| EINECS号 | |
| 相关类别 | 多肽;标准品 |
| Mol文件 | 729589-58-6.mol |
| 结构式 |  |
2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 性质
| 密度 | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 溶于H2O |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.91±0.46(Predicted) |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 1 mg/ml in water |
Proteinase-activated receptor 2 (PAR2)
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is equally effective to and 10 to 25 times more potent than SLIGRLNH
2
for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively.
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH
2
) is 10 to 300 times more potent than SLIGRL-NH
2
. Unlike trans-cinnamoyl-LIGRLO-NH
2
, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries.
Furoyl-LIGRLO-amide (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3 -/- mice. But it decreases significantly the number of scratches in WT mice.
| Animal Model: | Adult male (2/3-month-old) Trpv3 -/- and WT mice |
| Dosage: | 10 μg |
| Administration: | Injected intradermally at the nape of the neck |
| Result: | Was involved in PAR2- induced acute itch. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-P1314 | 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-Furoyl-LIGRLO-amide | 729589-58-6 | 1mg | 1200元 |
| 2024/04/30 | HY-P1314 | 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-Furoyl-LIGRLO-amide | 729589-58-6 | 5mg | 3600元 |