化合物 T14569
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- CAS号:
- 1875036-75-1
- 英文名:
- BI8626
- 英文别名:
- BI8626;BI8626
(BI-8626;N-[3-(Aminomethyl)benzyl]-8-(4-benzyl-1-piperazinyl)pyrimido[5,4-d]pyrimidin-4-amine;N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine;1,3-Benzenedimethanamine, N1-[8-[4-(phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]-
- 中文名:
- 化合物 T14569
- 中文别名:
- 化合物 T14569;N-[3-(氨甲基)苄基]-8-(4-苄基-1-哌嗪基)嘧啶并[5,4-D]嘧啶-4-胺
- CBNumber:
- CB14667639
- 分子式:
- C25H28N8
- 分子量:
- 440.56
- MOL File:
- 1875036-75-1.mol
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化合物 T14569化学性质
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沸点:
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654.4±55.0 °C(Predicted)
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密度:
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1.302±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 83.33 mg/mL (189.15 mM; Need ultrasonic)
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形态:
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Solid
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酸度系数(pKa):
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9.01±0.10(Predicted)
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颜色:
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Light yellow to yellow
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化合物 T14569性质、用途与生产工艺
BI8626 是一种泛素连接酶 HUWE1 特异性拮抗剂,IC50 为 0.9 μM。
BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells.
BI8626 suppresses colony formation of Ls174T cells with estimated IC
50
value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.
BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells.
Cell Cycle Analysis
Cell Line:
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Ls174T cells
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Concentration:
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0 μM, 5 μM,10 μM, 15 μM, 20 μM
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Incubation Time:
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0-4 days
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Result:
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Retarded passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.
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Western Blot Analysis
Cell Line:
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U2OS cells
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Concentration:
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0 μM, 20 μM, 50 μM
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Incubation Time:
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0 hour,1 hour,2 hours,4 hours,6 hours
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Result:
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Retarded the degradation of MCL1 in response to UV irradiation in HeLa cells by inhibiting HUWE1 in U2OS cells.
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化合物 T14569
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-120204 | 化合物 T14569 BI8626 | 1875036-75-1 | 5mg | 2500元 |
2024/04/30 | HY-120204 | 化合物 T14569 BI8626 | 1875036-75-1 | 10mM * 1mLin DMSO | 2750元 |
1875036-75-1, 化合物 T14569 相关搜索:
- C25H28N8
- N-[3-(氨甲基)苄基]-8-(4-苄基-1-哌嗪基)嘧啶并[5,4-D]嘧啶-4-胺
- 化合物 T14569
- 1875036-75-1
- N-[3-(Aminomethyl)benzyl]-8-(4-benzyl-1-piperazinyl)pyrimido[5,4-d]pyrimidin-4-amine
- N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine
- 1,3-Benzenedimethanamine, N1-[8-[4-(phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]-
- BI8626
- BI8626
(BI-8626