依维莫司杂质 DCP
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- CAS号:
- 147438-27-5
- 英文名:
- Seco Rapamycin
- 英文别名:
- Seco Rapamycin;Secorapamycin A;Seco Rapamycin Metamitron Impurity 4;Rapamycin Impurity 23;Temsirolimus Impurity; Temsirolimus Impurity 9;(Synonyms: Secorapamycin A);Secorapamycin A(Seco Rapamycin);Everolimus Impurity 15（Z&Emixture）
- 中文名:
- 依维莫司杂质 DCP
- 中文别名:
- 切拉帕霉素;西罗莫司杂质9;雷帕霉素杂质23;雷帕霉素(西罗莫司)杂质23;雷帕霉素杂质 5(赛科雷帕霉素);雷帕霉素杂质5(SECO雷帕霉素);依维莫司杂质15(Z&EMIXTURE);杂质SIROLIMUS-19-ENE OPEN RING;SECO RAPAMYCIN (SYNONYMS: SECORAPAMYCIN A)
- CBNumber:
- CB14668494
- 分子式:
- C51H79NO13
- 分子量:
- 914.19
- MOL File:
- 147438-27-5.mol
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依维莫司杂质 DCP化学性质
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沸点:
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965.7±75.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.24±0.20(Predicted)
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依维莫司杂质 DCP性质、用途与生产工艺
Seco Rapamycin (Secorapamycin A) 是 Rapamycin 的开环代谢物。Seco-Rapamycin 几乎不影响 mTOR 功能。
Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.
依维莫司杂质 DCP
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-19555 | 依维莫司杂质 DCP
Seco Rapamycin | | 1 mg | 1750元 |
| 2024/08/19 | HY-19555 | 依维莫司杂质 DCP
Seco Rapamycin | | 5 mg | 4360元 |
147438-27-5, 依维莫司杂质 DCP 相关搜索:
- 杂质对照品
- 科研试剂
- 依维莫司杂质15(Z&EMIXTURE)
- 雷帕霉素杂质 5(赛科雷帕霉素)
- 西罗莫司杂质9
- 雷帕霉素杂质23
- 切拉帕霉素
- 雷帕霉素杂质5(SECO雷帕霉素)
- 杂质SIROLIMUS-19-ENE OPEN RING
- 雷帕霉素(西罗莫司)杂质23
- SECO RAPAMYCIN (SYNONYMS: SECORAPAMYCIN A)
- 147438-27-5
- Everolimus Impurity 15（Z&Emixture）
- Temsirolimus Impurity
- Seco Rapamycin
- Temsirolimus Impurity 9
- Impurity Sirolimus-19-ene open ring
- Sirolimus-19-ene open ring impurity
- Metamitron Impurity 4
- Rapamycin Impurity 23
- Secorapamycin A, Technical Grade
DISCONTINUED PLEASE SEE R124010
- 2-Piperidinecarboxylic acid, 1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-, (2E...
- Seco Rapamycin
- (Synonyms: Secorapamycin A)
- Secorapamycin A
- Secorapamycin A(Seco Rapamycin)