依维莫司杂质 DCP
中文名称 | 依维莫司杂质 DCP |
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中文同义词 | SECO RAPAMYCIN (SYNONYMS: SECORAPAMYCIN A);雷帕霉素(西罗莫司)杂质23;杂质SIROLIMUS-19-ENE OPEN RING;雷帕霉素杂质5(SECO雷帕霉素);切拉帕霉素;雷帕霉素杂质23;西罗莫司杂质9;雷帕霉素杂质 5(赛科雷帕霉素) |
英文名称 | Seco Rapamycin |
英文同义词 | Secorapamycin A(Seco Rapamycin);Secorapamycin A;(Synonyms: Secorapamycin A);Seco Rapamycin 2-Piperidinecarboxylic acid, 1-[2-oxo-2-[(2R,3R,6S)-tetrahydro-2-hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaen-1-yl]-3-methyl-2H-pyran-2-yl]acetyl]-, (2E...;Secorapamycin A, Technical Grade DISCONTINUED PLEASE SEE R124010;Rapamycin Impurity 23;Metamitron Impurity 4 |
CAS号 | 147438-27-5 |
分子式 | C51H79NO13 |
分子量 | 914.19 |
EINECS号 | |
相关类别 | 科研试剂 |
Mol文件 | 147438-27-5.mol |
结构式 | ![]() |
依维莫司杂质 DCP 性质
沸点 | 965.7±75.0 °C(Predicted) |
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密度 | 1.17±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.24±0.20(Predicted) |
Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.