PIP-199
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- CAS号:
- 622795-76-0
- 英文名:
- PIP-199
- 英文别名:
- PIP-199;PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester
- 中文名:
- PIP-199
- 中文别名:
- 化合物 T9126
- CBNumber:
- CB14718650
- 分子式:
- C27H28N4O3
- 分子量:
- 456.55
- MOL File:
- 622795-76-0.mol
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PIP-199化学性质
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沸点:
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655.1±65.0 °C(Predicted)
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密度:
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1.26±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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13.19±0.58(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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PIP-199性质、用途与生产工艺
PIP-199 是一种 RecQ 介导的基因组不稳定蛋白 RMI 核心复合物/MM2 相互作用 (RMI core complex/MM2 interaction) 的选择性抑制剂，其 IC50 值为 36 μM。PIP-199 可用于耐受肿瘤对 DNA 交联化疗药物的增敏研究。
IC50: 36 μM (RMI core complex/MM2 interaction)
MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM).
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies.
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents.
PIP-199
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-124325 | PIP-199
PIP-199 | 622795-76-0 | 5mg | 5850元 |
| 2024/01/25 | HY-124325 | PIP-199 | | 1 mg | 2340元 |
622795-76-0, PIP-199 相关搜索:
- 制剂-抑制剂
- 化合物 T9126
- 622795-76-0
- 1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester
- PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate
- PIP-199