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PIP-199

PIP-199 structure

CAS No.: 622795-76-0

Chemical Name:: PIP-199

Synonyms: PIP-199;PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester

CBNumber:: CB14718650

Molecular Formula:: C27H28N4O3

Molecular Weight:: 456.55

MDL Number:: MFCD04443596

MOL File:: 622795-76-0.mol

Last updated:2024-07-02 08:55:01

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PIP-199 Properties

Boiling point	655.1±65.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	13.19±0.58(Predicted)
form	Solid
color	White to off-white

PIP-199 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0086206	PIP-199 ≥98.0%	622795-76-0	5mg	$450	2021-12-16	Buy
ChemScene	CS-0086206	PIP-199 ≥98.0%	622795-76-0	10mg	$770	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0086206	5mg	$450	Buy
CS-0086206	10mg	$770	Buy

PIP-199 Chemical Properties,Uses,Production

Biological Activity

PIP-199 is a selective inhibitor of the RecQ-mediated RMI core complex/MM2 interaction of genomically unstable proteins with IC50 of 36 μM. PIP-199 can be used to sensitize resistant tumors to DNA cross-linking chemotherapeutics.

in vitro

MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM).
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies.
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents.

target

IC50: 36 μM (RMI core complex/MM2 interaction)

PIP-199 Preparation Products And Raw materials

Raw materials

Preparation Products

PIP-199 Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4296	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	507	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	891	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9268	58

Supplier	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Yu Ben Biotechnology Co., Ltd.	58
Beijing Biocreative Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
RD International Technology Co., Limited	58

PIP-199 PIP-199 ethyl 4-((1-hydroxy-2-phenyl-1H-indol-3-yl)(pyridin-2-yl)methyl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-[(1-hydroxy-2-phenyl-1H-indol-3-yl)-2-pyridinylmethyl]-, ethyl ester 622795-76-0