142477-34-7
|
|
|
- CAS号:
- 142477-34-7
- 英文名:
- 5-HT1A modulator 1
- 英文别名:
- 5-HT1A modulator 1;2(3H)-Benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-
- 中文名:
- 142477-34-7
- 中文别名:
- 化合物 T10168;化合物5-HT1A MODULATOR 1
- CBNumber:
- CB14796630
- 分子式:
- C21H25N3O2S
- 分子量:
- 383.51
- MOL File:
- 142477-34-7.mol
|
|
|
142477-34-7化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
142477-34-7性质、用途与生产工艺
5-HT1A modulator 1 对 5HT1A，肾上腺素能 α1 和多巴胺 D2 受体具有非常高的亲和力，IC50 分别为 2±0.3 nM，10±3 nM 和 40±9 nM。
|
sPLA2
2 nM (IC
50
)
|
5-HT
2A
Receptor
500 nM (IC
50
)
|
5-HT
2C
Receptor
4000 nM (IC
50
)
|
α1 receptor
10 nM (IC
50
)
|
D2 receptor
40 nM (IC
50
)
|
5-HT1A modulator 1 (Compound 24) also displays affinities for the 5HT
1B
, 5-HT
2A
and 5-HT
2C
receptor with IC
50
s of 300±55 nM, 500±75 nM, and 4000±440 nM, respectively.
5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT
2A
receptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01).
142477-34-7
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100290 | 142477-34-7
5-HT1A modulator 1 | 142477-34-7 | 1mg | 5600元 |
142477-34-7, 142477-34-7 相关搜索:
- 化合物5-HT1A MODULATOR 1
- 化合物 T10168
- 142477-34-7
- 2(3H)-Benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-
- 5-HT1A modulator 1