142477-34-7
| 中文名称 | 142477-34-7 |
|---|---|
| 中文同义词 | 化合物 T10168;化合物5-HT1A MODULATOR 1 |
| 英文名称 | 5-HT1A modulator 1 |
| 英文同义词 | 5-HT1A modulator 1;2(3H)-Benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl- |
| CAS号 | 142477-34-7 |
| 分子式 | C21H25N3O2S |
| 分子量 | 383.51 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 142477-34-7.mol |
| 结构式 |  |
142477-34-7 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
|
sPLA2 2 nM (IC 50 ) |
5-HT 2A Receptor 500 nM (IC 50 ) |
5-HT 2C Receptor 4000 nM (IC 50 ) |
α1 receptor 10 nM (IC 50 ) |
D2 receptor 40 nM (IC 50 ) |
5-HT1A modulator 1 (Compound 24) also displays affinities for the 5HT 1B , 5-HT 2A and 5-HT 2C receptor with IC 50 s of 300±55 nM, 500±75 nM, and 4000±440 nM, respectively.
5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT 2A receptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100290 | 142477-34-7 5-HT1A modulator 1 | 142477-34-7 | 1mg | 3200元 |