E1R
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- CAS号:
- 1301211-78-8
- 英文名:
- E1R
- 英文别名:
- E1R;E1R,E-1R;1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-
- 中文名:
- E1R
- 中文别名:
- 化合物 T10093L
- CBNumber:
- CB15821375
- 分子式:
- C13H16N2O2
- 分子量:
- 232.28
- MOL File:
- 1301211-78-8.mol
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E1R化学性质
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沸点:
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480.0±45.0 °C(Predicted)
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密度:
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1.168±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 60 mg/mL (258.31 mM)
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酸度系数(pKa):
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15.67±0.40(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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E1R性质、用途与生产工艺
E1R 是一种 sigma-1 受体的正变构调节剂 (Sig1R PAM)，具有认知增强效果。
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([
3
H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice.
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Animal Model:
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Male ICR and Balb/c mice weighed 23-25 g
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Dosage:
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0.1, 1 and 10 mg/kg
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Administration:
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Administered i.p. 60 min before the training session
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Result:
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Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
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E1R
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-116463 | E1R | | 1 mg | 1200元 |
| 2024/04/30 | HY-116463 | E1R
E1R | 1301211-78-8 | 5mg | 3000元 |
1301211-78-8, E1R 相关搜索:
- 化合物 T10093L
- 1301211-78-8
- E1R,E-1R
- 1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-
- E1R