E1R
| 中文名称 | E1R |
|---|---|
| 中文同义词 | 化合物 T10093L |
| 英文名称 | E1R |
| 英文同义词 | E1R;1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-;E1R,E-1R |
| CAS号 | 1301211-78-8 |
| 分子式 | C13H16N2O2 |
| 分子量 | 232.28 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1301211-78-8.mol |
| 结构式 |  |
E1R 性质
| 沸点 | 480.0±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.168±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：60 mg/ml（258.31 mM） |
| 酸度系数(pKa) | 15.67±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
E1R 是一种 sigma-1 受体的正变构调节剂 (Sig1R PAM)，具有认知增强效果。
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice.
| Animal Model: | Male ICR and Balb/c mice weighed 23-25 g |
| Dosage: | 0.1, 1 and 10 mg/kg |
| Administration: | Administered i.p. 60 min before the training session |
| Result: | Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-116463 | E1R | 1 mg | 1200元 | |
| 2024/04/30 | HY-116463 | E1R E1R | 1301211-78-8 | 5mg | 3000元 |