E1R

E1R Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:E1R
CAS:1301211-78-8
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:E1R
CAS:1301211-78-8
Purity:99% Package:$350.9/5mg;$550.9/10mg;$990.9/25mg;$1650.9/50mg;$2250.9/100mg;Bulk package Remarks:99%
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com
Products Intro: Product Name:E1R
CAS:1301211-78-8
Purity:97.0% Package:5mg
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:E1R
CAS:1301211-78-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Email: hongquchem@qq.com
Products Intro: Product Name:E1R
CAS:1301211-78-8
Purity:98% Package:100mg;1g;10g;100g;1kg
E1R Basic information
Product Name:E1R
Synonyms:E1R;1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)-;E1R,E-1R
CAS:1301211-78-8
MF:C13H16N2O2
MW:232.28
EINECS:
Product Categories:
Mol File:1301211-78-8.mol
E1R Structure
E1R Chemical Properties
Boiling point 480.0±45.0 °C(Predicted)
density 1.168±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 60 mg/mL (258.31 mM)
pka15.67±0.40(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
E1R Usage And Synthesis
Biological ActivityE1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) with cognitive enhancing effects.
in vitro

The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.

in vivo

E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered ip 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice .

Animal Model: Male ICR and Balb/c mice weighed 23-25 g
Dosage: 0.1, 1 and 10 mg/kg
Administration: Administered ip 60 min before the training session
Result: Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
E1R Preparation Products And Raw materials
Tag:E1R(1301211-78-8) Related Product Information