Corynoxine hydrochloride
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- CAS号:
- 英文名:
- Corynoxine hydrochloride
- 英文别名:
- Corynoxine hydrochloride
- 中文名:
- Corynoxine hydrochloride
- 中文别名:
- 柯诺辛碱盐酸盐
- CBNumber:
- CB18078493
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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Corynoxine hydrochloride化学性质
Corynoxine hydrochloride性质、用途与生产工艺
Corynoxine hydrochloride 是一种从 Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过 Akt/mTOR 途径促进 α-突触核蛋白的清除。
Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction.
Western Blot Analysis
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Cell Line:
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N2a and SH-SY5Y cells
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Concentration:
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6.25, 12.5, 25 μM
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Incubation Time:
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6, 12 hours
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Result:
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Induced autophagy in neuronal cell lines.
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Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.
Corynoxine hydrochloride
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Corynoxine hydrochloride
生产厂家
Corynoxine hydrochloride 相关搜索:
- 柯诺辛碱盐酸盐
- Corynoxine hydrochloride