Corynoxine hydrochloride
| 中文名称 | Corynoxine hydrochloride |
|---|---|
| 中文同义词 | 柯诺辛碱盐酸盐 |
| 英文名称 | Corynoxine hydrochloride |
| 英文同义词 | Corynoxine hydrochloride |
| CAS号 | |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
Corynoxine hydrochloride 性质
Corynoxine hydrochloride 是一种从 Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过 Akt/mTOR 途径促进 α-突触核蛋白的清除。
Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction.
Western Blot Analysis
| Cell Line: | N2a and SH-SY5Y cells |
| Concentration: | 6.25, 12.5, 25 μM |
| Incubation Time: | 6, 12 hours |
| Result: | Induced autophagy in neuronal cell lines. |
Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.