SSD114 HYDROCHLORIDE
|
|
- CAS号:
- 2319790-02-6
- 英文名:
- SSD114 hydrochloride
- 英文别名:
- SSD114 HCl (SSD114 Hydrochloride)
- 中文名:
- SSD114 HYDROCHLORIDE
- 中文别名:
- SSD114盐酸盐
- CBNumber:
- CB18280362
- 分子式:
- C18H21ClF3N3O
- 分子量:
- 387.83
- MOL File:
- 2319790-02-6.mol
|
|
|
SSD114 HYDROCHLORIDE化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to off-white
-
|
SSD114 HYDROCHLORIDE性质、用途与生产工艺
SSD114 hydrochloride 是一种新型 GABAB 受体正变构调节剂。
In the presence of 10 µM GABA, SSD114 hydrochloride at 25 µM significantly increases (to approximately 170% above basal levels) the [
35
S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 µM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 µM SSD114 hydrochloride, the EC
50
for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 µM, reaching 161±5.09% over the basal value .
The onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F
(5,30)
=4.55, P<0.005].
Post hoc
analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F
(5,30)
=4.81, P<0.005].
Post hoc
analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.
SSD114 HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2023/01/06 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 25mg | 4644.53元 |
2021/03/30 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 5mg | 1548.79元 |
SSD114 HYDROCHLORIDE
生产厂家
2319790-02-6, SSD114 HYDROCHLORIDE 相关搜索:
- 抑制剂
- 药靶配体
- SSD114盐酸盐
- 2319790-02-6
- SSD114 HCl (SSD114 Hydrochloride)