SSD114 HYDROCHLORIDE
中文名称 | SSD114 HYDROCHLORIDE |
---|---|
中文同义词 | SSD114盐酸盐 |
英文名称 | SSD114 hydrochloride |
英文同义词 | SSD114 HCl (SSD114 Hydrochloride) |
CAS号 | 2319790-02-6 |
分子式 | C18H21ClF3N3O |
分子量 | 387.83 |
EINECS号 | |
相关类别 | |
Mol文件 | 2319790-02-6.mol |
结构式 |
SSD114 HYDROCHLORIDE 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
GABA B receptor
In the presence of 10 µM GABA, SSD114 hydrochloride at 25 µM significantly increases (to approximately 170% above basal levels) the [ 35 S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 µM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 µM SSD114 hydrochloride, the EC 50 for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 µM, reaching 161±5.09% over the basal value .
The onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F (5,30) =4.55, P<0.005]. Post hoc analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F (5,30) =4.81, P<0.005]. Post hoc analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2023/01/06 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 25mg | 4644.53元 |
2021/03/30 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 5mg | 1548.79元 |