ARP100
|
|
|
- CAS号:
- 704888-90-4
- 英文名:
- ARP100
- 英文别名:
- ARP100;MMP-2 Inhibitor III;N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide;N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide;N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide;N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide;2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide;Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-;metalloproteinase,Inhibitor,Matrix metalloproteinases,selective,matrigel,ARP 100,matrix,invasion,ARP100,anti-invasive,MMP,ARP-100,inhibit
- 中文名:
- ARP100
- 中文别名:
- 化合物ARP-100;ARP 100,MMP-2的抑制剂;N-羟基-2-(N-异丙氧基联苯-4-磺酰胺)乙酰胺
- CBNumber:
- CB21075595
- 分子式:
- C17H20N2O5S
- 分子量:
- 364.42
- MOL File:
- 704888-90-4.mol
|
|
|
ARP100化学性质
-
储存条件:
-
Desiccate at +4°C
-
|
-
溶解度:
-
Soluble at 100mM in DMSO
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Off-white to light yellow
-
|
ARP100性质、用途与生产工艺
ARP 100是一种有效的MMP-12/MMP-13靶点的双重抑制剂，MMP-12/MMP-13靶点是一个锌依赖性内肽酶家族，已知在细胞外基质（ECM）分解障碍中起关键作用，如类风湿性关节炎（RA）和骨关节炎（OA）两种主要形式的关节炎。
ARP-100 是一种有效的选择性基质金属蛋白酶 MMP-2 抑制剂 (IC50=12 nM)。ARP-100 与 MMP-2 的 S1＇ 口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。ARP-100 对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。
|
MMP-2
12 nM (IC
50
)
|
MMP-9
0.2 μM (IC
50
)
|
MMP-3
4.5 μM (IC
50
)
|
MMP-1
>50 μM (IC
50
)
|
MMP-7
>50 μM (IC
50
)
|
ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations.
ARP100
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-103444 | ARP100
ARP-100 | 704888-90-4 | 5mg | 800元 |
| 2024/08/19 | HY-103444 | ARP100
ARP-100 | 704888-90-4 | 10mM * 1mLin DMSO | 880元 |
704888-90-4, ARP100 相关搜索:
- 抑制剂
- 合成有机化合物配体
- 小分子
- ARP 100,MMP-2的抑制剂
- 化合物ARP-100
- N-羟基-2-(N-异丙氧基联苯-4-磺酰胺)乙酰胺
- 704888-90-4
- N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide
- metalloproteinase,Inhibitor,Matrix metalloproteinases,selective,matrigel,ARP 100,matrix,invasion,ARP100,anti-invasive,MMP,ARP-100,inhibit
- N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide
- Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-
- N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
- MMP-2 Inhibitor III
- 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
- N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide
- ARP100