苯乙酸芥末-D8
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- CAS号:
- 10477-72-2
- 英文名:
- phenacid
- 英文别名:
- CB-1331;phenacid;NSC-71964;Phenylacetic acid mustard;Phenylacetic acid Mustard-d8;p-[Bis(2-chloroethyl)amino]phenylacetic acid;4-[Bis(2-chloroethyl)amino]benzeneacetic acid;Benzeneacetic acid, 4-[bis(2-chloroethyl)amino]-;2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid
- 中文名:
- 苯乙酸芥末-D8
- 中文别名:
- 苯乙酸芥末;苯芥-D3;苯乙酸芥末-D8
- CBNumber:
- CB21366556
- 分子式:
- C12H15Cl2NO2
- 分子量:
- 276.16
- MOL File:
- 10477-72-2.mol
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苯乙酸芥末-D8化学性质
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熔点:
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105 °C(Solv: benzene (71-43-2); pentane (109-66-0))
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沸点:
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125°C (rough estimate)
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密度:
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1.2884 (rough estimate)
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折射率:
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1.6070 (estimate)
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酸度系数(pKa):
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3.86±0.10(Predicted)
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苯乙酸芥末-D8性质、用途与生产工艺
Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator)，具有抗肿瘤活性。
IC50: metabolite of Chlorambucil
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than
CHL, it exhibits an ED
15
value of 8.0 mg/kg.Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg.
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Animal Model:
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Inbred male C3H/He mice
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Dosage:
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0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
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Administration:
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Intraperitoneal injection; 15 days
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Result:
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Exhibited anti-tumor activities in vivo.
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苯乙酸芥末-D8
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下游产品
10477-72-2, 苯乙酸芥末-D8 相关搜索:
- 苯乙酸芥末
- 苯芥-D3
- 苯乙酸芥末-D8
- 10477-72-2
- Benzeneacetic acid, 4-[bis(2-chloroethyl)amino]-
- 2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid
- Phenylacetic acid Mustard-d8
- Phenylacetic acid mustard
- p-[Bis(2-chloroethyl)amino]phenylacetic acid
- NSC-71964
- CB-1331
- 4-[Bis(2-chloroethyl)amino]benzeneacetic acid
- phenacid