苯乙酸芥末-D8
中文名称 | 苯乙酸芥末-D8 |
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中文同义词 | 苯乙酸芥末-D8;苯芥-D3;苯乙酸芥末 |
英文名称 | phenacid |
英文同义词 | phenacid;4-[Bis(2-chloroethyl)amino]benzeneacetic acid;CB-1331;NSC-71964;p-[Bis(2-chloroethyl)amino]phenylacetic acid;Phenylacetic acid mustard;Phenylacetic acid Mustard-d8;2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid |
CAS号 | 10477-72-2 |
分子式 | C12H15Cl2NO2 |
分子量 | 276.16 |
EINECS号 | |
相关类别 | |
Mol文件 | 10477-72-2.mol |
结构式 |
苯乙酸芥末-D8 性质
熔点 | 105 °C(Solv: benzene (71-43-2); pentane (109-66-0)) |
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沸点 | 125°C (rough estimate) |
密度 | 1.2884 (rough estimate) |
折射率 | 1.6070 (estimate) |
酸度系数(pKa) | 3.86±0.10(Predicted) |
Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator),具有抗肿瘤活性。
IC50: metabolite of Chlorambucil
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED 15 value of 8.0 mg/kg.Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg.
Animal Model: | Inbred male C3H/He mice |
Dosage: | 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg |
Administration: | Intraperitoneal injection; 15 days |
Result: | Exhibited anti-tumor activities in vivo. |
安全信息
海关编码 | 2916340000 |
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毒性 | sln-dmg-par 3 mmol/L GENRA81,173,60 |