BK
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- CAS号:
- 58-82-2
- 英文名:
- BRADYKININ
- 英文别名:
- bk;brs640;prs640;C00306;RPPGFSPFR;BRADYZIDE;Callideic;KallidinⅠ;BRADYKININ;Callidin I
- 中文名:
- BK
- 中文别名:
- 舒缓激肽;BK 舒缓激肽;缓激肽, >98%;缓激肽BRADYKININ;化合物BRADYKININ;BRADYKININ游离态;亮氨酸脑啡肽 乙酸盐 水合物;舒缓激肽H-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH;L-精氨酰基-L-脯氨酰-L-脯氨酰甘氨酰基-L-苯丙氨酰基-L-丝氨酰基-L-脯氨酰-L-苯丙氨酰基-L-精氨酸;[DES-PRO2]-BRADYKININ; ANGIOTENSIN I CONVERTING ENZYME (ACE I) INHIBITOR
- CBNumber:
- CB2141633
- 分子式:
- C50H73N15O11
- 分子量:
- 1060.21
- MOL File:
- 58-82-2.mol
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BK化学性质
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熔点:
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170°C (rough estimate)
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沸点:
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811.85°C (rough estimate)
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比旋光度:
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D25 -76.5° (c = 1.37 in 1N acetic acid)
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密度:
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1.1171 (rough estimate)
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折射率:
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1.6930 (estimate)
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RTECS号:
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EE1530000
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储存条件:
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−20°C
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溶解度:
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H2O: >40 mg/mL
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酸度系数(pKa):
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3.34±0.10(Predicted)
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形态:
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White to off-white lyophilized solid
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颜色:
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Lyophilized powder
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水溶解性:
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Soluble to 1 mg/ml in water.
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序列:
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H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
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CAS 数据库:
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58-82-2
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BK性质、用途与生产工艺
Bradykinin是由激肽释放酶-激肽系统产生的活性肽。 它是炎症调节因子，也被认为是几种血管和肾功能以及神经调节因子。
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Human Endogenous Metabolite
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Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. Bradykinin has been reported to be involved in the progression of many types of cancer. Bradykinin treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin treatment stimulates ERK1/2 activation and IL-6 production. Exogenous bradykinin markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin on tissue factor expression.
Application of 1 μM bradykinin to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact. Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increases gradually after 48 h. PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA;B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
类别
有毒物品
毒性分级
剧毒
急性毒性
腹腔-大鼠 TDL0:0.00053 毫克/公斤;静脉-大鼠TDL0:0.000212毫克/公斤
可燃性危险特性
热分解排出有毒氮氧化物气体
储运特性
库房通风, 低温, 干燥, 密闭, 与食品原料分开存放
灭火剂
水,泡沫,沙土,二氧化碳,干粉
BK
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生产厂家
全球有 95家供应商
BK国内生产厂家
58-82-2, BK 相关搜索:
- Chemical and pharmaceutical intermediates
- peptide
- 化学试剂
- 抑制剂
- 配体家族
- 目录肽
- 目录多肽
- 多肽-客户肽
- 多肽
- Peptides
- Amino Acids and Peptides
- BioChemical
- Biochemicals and Reagents
- Bradykinins
- L-精氨酰基-L-脯氨酰-L-脯氨酰甘氨酰基-L-苯丙氨酰基-L-丝氨酰基-L-脯氨酰-L-苯丙氨酰基-L-精氨酸
- 缓激肽BRADYKININ
- 化合物BRADYKININ
- 舒缓激肽H-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH
- BRADYKININ游离态
- [DES-PRO2]-BRADYKININ; ANGIOTENSIN I CONVERTING ENZYME (ACE I) INHIBITOR
- 缓激肽, >98%
- 舒缓激肽
- BK 舒缓激肽
- 亮氨酸脑啡肽 乙酸盐 水合物
- 58-82-2
- L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine
- Bradykinin Receptor,Bradykinin,Serine endopeptidases,inhibit,Threonine proteases,Inhibitor,Endogenous Metabolite,Serine proteases,Ser/Thr Protease
- Bradykinin, >98%
- Bradykinin - CAS 58-82-2 - Calbiochem
- Leucine Enkephalin acetate salt hydrate
- C00306
- KallidinⅠ
- Callideic
- Kallidin I
- Kallidin 9
- Callidin I
- Synthetic bradykinin
- BRADYZIDE
- prs640
- brs640
- bradykinin(synthetic)
- bk
- H-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH
- ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG
- BRADYKININ (HUMAN, BOVINE, RAT, MOUSE)
- BRADYKININ, HUMAN
- BRADYKININ, METHIONYL-LYSYL
- BRADYKININ, LYSYL
- BRADYKININ, TYROSYL
- BRADYKININ
- RPPGFSPFR