二茂铁氯喹
|
|
- CAS号:
- 185055-67-8
- 英文名:
- FERROQUINE
- 英文别名:
- SSR 97193;FERROQUINE;Ferrochloroquine;7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline
- 中文名:
- 二茂铁氯喹
- 中文别名:
- 二茂铁氯喹;化合物 T15276
- CBNumber:
- CB21509113
- 分子式:
- C18H19ClN3.C5H5.Fe
- 分子量:
- 433.762
- MOL File:
- 185055-67-8.mol
|
|
|
二茂铁氯喹化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO : 8.33 mg/mL (19.20 mM)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Light yellow to orange
-
|
二茂铁氯喹性质、用途与生产工艺
Ferroquine (Ferrochloroquine),是 Chloroquine 的二茂铁基类似物,是一种抗疟疾剂。Ferroquine 通过诱导氧化应激和随后的膜破坏而对疟原虫表现出杀虫作用。
Ferroquine shows cytotoxicity against non-cancerous MRC-5 and HeLa cancer cells with IC
50
values of 24.4 µM and 16.8 µM, respectively.
24 hours post-incubation all newly transformed schistosomula (NTS) exposed to 33.3 µM Ferroquine shows strongly reduced viabilities.
Treatment of mice with 200 and 800 mg/kg Ferroquine, shows low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800 mg/kg Ferroquine died within 24 hours post-treatment. No activity is observed treating mice with RQ at 200 mg/kg. Finally, a total worm burden reduction of 17.3% is observed following treatment with FQ-OH. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. For comparison, at 200 mg/kg mefloquine (MQ) achieves a much higher worm burden reduction of 72.3% in
S. mansoni
-infected mice. A higher effect against female adult
S. mansoni
is also observed in MQ treated mice pointing to a sex-specific interference of these drugs with the target. Furthermore, in one of the FQ-OH treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and FQ-OH show weak antischistosomal activity in vivo.
二茂铁氯喹
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-19364 | 二茂铁氯喹 Ferroquine | 185055-67-8 | 2mg | 650元 |
2024/08/19 | HY-19364 | 二茂铁氯喹 Ferroquine | 185055-67-8 | 5mg | 1360元 |
185055-67-8, 二茂铁氯喹 相关搜索:
- C23H24ClFeN3
- 化合物 T15276
- 二茂铁氯喹
- 185055-67-8
- SSR 97193
- Ferrochloroquine
- 7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline
- FERROQUINE