二茂铁氯喹
中文名称 | 二茂铁氯喹 |
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中文同义词 | 二茂铁氯喹;化合物 T15276 |
英文名称 | FERROQUINE |
英文同义词 | FERROQUINE;7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline;Ferrochloroquine;SSR 97193 |
CAS号 | 185055-67-8 |
分子式 | C18H19ClN3.C5H5.Fe |
分子量 | 433.762 |
EINECS号 | |
相关类别 | |
Mol文件 | 185055-67-8.mol |
结构式 |
二茂铁氯喹 性质
储存条件 | Store at -20°C |
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溶解度 | 二甲基亚砜:8.33 mg/mL(19.20 mM) |
形态 | 固体 |
颜色 | 浅黄至橙色 |
antimalarial
Ferroquine shows cytotoxicity against non-cancerous MRC-5 and HeLa cancer cells with IC
50
values of 24.4 µM and 16.8 µM, respectively.
24 hours post-incubation all newly transformed schistosomula (NTS) exposed to 33.3 µM Ferroquine shows strongly reduced viabilities.
Treatment of mice with 200 and 800 mg/kg Ferroquine, shows low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800 mg/kg Ferroquine died within 24 hours post-treatment. No activity is observed treating mice with RQ at 200 mg/kg. Finally, a total worm burden reduction of 17.3% is observed following treatment with FQ-OH. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. For comparison, at 200 mg/kg mefloquine (MQ) achieves a much higher worm burden reduction of 72.3% in S. mansoni -infected mice. A higher effect against female adult S. mansoni is also observed in MQ treated mice pointing to a sex-specific interference of these drugs with the target. Furthermore, in one of the FQ-OH treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and FQ-OH show weak antischistosomal activity in vivo.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-19364 | 二茂铁氯喹 Ferroquine | 185055-67-8 | 2mg | 650元 |
2024/04/30 | HY-19364 | 二茂铁氯喹 Ferroquine | 185055-67-8 | 5mg | 1360元 |