盐酸阿柔比星
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- CAS号:
- 75443-99-1
- 英文名:
- ACLARUBICIN HYDROCHLORIDE
- 英文别名:
- aclacinon;Aclarubicin HCl;Aclarubicin hydrochlride;ACLARUBICIN HYDROCHLORIDE;aclacinomycinahydrochloride;ACLARUBICIN HYDROCHLORIDE USP/EP/BP;Aclarubicin hydrochloride (Aclacinomycin A);syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
- 中文名:
- 盐酸阿柔比星
- 中文别名:
- 盐酸阿柔比星;阿柔比星盐酸盐;阿克拉霉素盐酸盐
- CBNumber:
- CB2189954
- 分子式:
- C42H54ClNO15
- 分子量:
- 848.33
- MOL File:
- 75443-99-1.mol
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盐酸阿柔比星化学性质
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熔点:
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151-153℃
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沸点:
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898℃
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闪点:
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>110°(230°F)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO or DMF at 25mg/ml
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形态:
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Solid
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颜色:
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Light yellow to yellow
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盐酸阿柔比星性质、用途与生产工艺
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。
20S proteasome.
Topoisomerase I and II.
Aclacinomycin A could efficiently enter living cells and emit fluorescence
in situ
. Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD
50
(76.5 mg/kg) is about twice the iv LD
50
(35.6 mg/kg) in mice
[4
.
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model
[4
.
Animal Model:
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DBA/2, CDF
1
(BALB/c×DBA/2) mice with Leukemia P-388
[4
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Dosage:
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0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
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Administration:
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Intraperitoneal administration daily for 10 days starting 3 hr after transplantation.
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Result:
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Inhibited tumor growth.
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盐酸阿柔比星
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2023/01/06 | HY-N2306A | 盐酸阿柔比星 Aclacinomycin A hydrochloride | 75443-99-1 | 5mg | 2800元 |
2023/01/06 | HY-N2306A | 盐酸阿柔比星 Aclacinomycin A hydrochloride | 75443-99-1 | 10 mM * 1 mLin DMSO | 4479元 |
75443-99-1, 盐酸阿柔比星 相关搜索:
- API
- C42H53NO15HCl
- C42H54ClNO15
- 阿克拉霉素盐酸盐
- 阿柔比星盐酸盐
- 盐酸阿柔比星
- 75443-99-1
- methyl(1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate,hydrochloride
- ACLARUBICIN HYDROCHLORIDE USP/EP/BP
- Aclarubicin hydrochloride (Aclacinomycin A)
- Aclarubicin HCl
- Aclarubicin hydrochlride
- 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
- 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth
- ACLARUBICIN HYDROCHLORIDE
- 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
- syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4
- n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano
- aclacinon
- aclacinomycinahydrochloride