UK-37248
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- CAS号:
- 74226-22-5
- 英文名:
- UK-37248
- 英文别名:
- UK-37248;UK-37248-01;Dazoxiben HCl;Dazoxiben hydrochloride;Dazoxiben,Inhibitor,inhibit;4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride
- 中文名:
- UK-37248
- 中文别名:
- 盐酸达唑苄;盐酸达唑氧苯;化合物UK-37248;4-(2-(1H-咪唑-1-基)乙氧基)苯甲酸盐酸盐
- CBNumber:
- CB22397047
- 分子式:
- C12H13ClN2O3
- 分子量:
- 268.69622
- MOL File:
- 74226-22-5.mol
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UK-37248化学性质
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熔点:
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230-235 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO:58.0(Max Conc. mg/mL);215.86(Max Conc. mM)
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形态:
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Solid
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颜色:
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White to off-white
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UK-37248性质、用途与生产工艺
Dazoxiben hydrochloride (HCl) 是一种 thromboxane (TX) synthase.的有效，选择性和口服活性抑制剂。Dazoxiben 可抑制人全血中 TXB2 的产生，其IC50值为0.3 μM，并可平行地增强 PGE2 的产生。
| Target | Value |
PGE2
()
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TXB2
(Cell-free assay)
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0.3 μM
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Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC
50
of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production.
Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC
50
of 1.60 μM) than in rat whole blood (IC
50
= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production.
Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.
UK-37248
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S0541 | UK-37248
Dazoxiben hydrochloride | 74226-22-5 | 5mg | 1168.08元 |
| 2024/04/30 | S0541 | UK-37248
Dazoxiben hydrochloride | 74226-22-5 | 25mg | 3976.74元 |
74226-22-5, UK-37248 相关搜索:
- 药靶配体
- 4-(2-(1H-咪唑-1-基)乙氧基)苯甲酸盐酸盐
- 化合物UK-37248
- 盐酸达唑氧苯
- 盐酸达唑苄
- 74226-22-5
- Dazoxiben,Inhibitor,inhibit
- Dazoxiben HCl
- 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride
- UK-37248-01
- UK-37248
- Dazoxiben hydrochloride