108477-18-5
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- CAS号:
- 108477-18-5
- 英文名:
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- 英文别名:
- NSC-144303;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide;tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
- 中文名:
- 108477-18-5
- 中文别名:
- 化合物 T17192;3,5-双(4-硝基亚苄基)四氢-4H-硫代吡喃-4-酮 1,1-二氧化物;半胱天冬酶和细胞凋亡激活剂(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5)
- CBNumber:
- CB22489683
- 分子式:
- C19H14N2O7S
- 分子量:
- 414.39
- MOL File:
- 108477-18-5.mol
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108477-18-5化学性质
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熔点:
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233.5-234.5 °C
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沸点:
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693.0±55.0 °C(Predicted)
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密度:
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1.541±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C,unstable in solution, ready to use.
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溶解度:
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≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
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形态:
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crystalline solid
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颜色:
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Light yellow to yellow
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108477-18-5性质、用途与生产工艺
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the
inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC
50
s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
108477-18-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-100738 | 108477-18-5
Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2024/08/19 | HY-100738 | 108477-18-5
Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |
108477-18-5, 108477-18-5 相关搜索:
- 细胞生物学试剂
- C19H14N2O7S
- 3,5-双(4-硝基亚苄基)四氢-4H-硫代吡喃-4-酮 1,1-二氧化物
- 化合物 T17192
- 半胱天冬酶和细胞凋亡激活剂(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5)
- 108477-18-5
- 3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide
- tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t
- 3,5-Bis[(4-nitrophenyl)methylene]-2,3,5,6-tetrahydro-4H-thiopyran-4-one-1,1-dioxide
- 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide
- Ubiquitin Isopeptidase Inhibitor I, G5,Ubiquitin Isopeptidase Inhibitor I, G-5
- Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303)
- Ubiquitin Isopeptidase-IN-G5
- G5, Ubiquitin Isopeptidase Inhibitor I
- Ubiquitin Isopeptidase Inhibitor I, G5
- Ubiquitin Isopeptidase Inhibitor I
- NSC-144303
- 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide