108477-18-5
| 中文名称 | 108477-18-5 |
|---|---|
| 中文同义词 | 半胱天冬酶和细胞凋亡激活剂(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5);化合物 T17192;3,5-双(4-硝基亚苄基)四氢-4H-硫代吡喃-4-酮 1,1-二氧化物;UBIQUITIN ISOPEPTIDASE 抑制剂I |
| 英文名称 | 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide |
| 英文同义词 | 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide;NSC-144303;Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);Ubiquitin Isopeptidase Inhibitor I, G5,Ubiquitin Isopeptidase Inhibitor I, G-5 |
| CAS号 | 108477-18-5 |
| 分子式 | C19H14N2O7S |
| 分子量 | 414.39 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 108477-18-5.mol |
| 结构式 |  |
108477-18-5 性质
| 熔点 | 233.5-234.5 °C |
|---|---|
| 沸点 | 693.0±55.0 °C(Predicted) |
| 密度 | 1.541±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | DMSO 中≤15mg/ml；二甲基甲酰胺中≤1mg/ml |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至黄色 |
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC 50 s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2024/08/19 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |