甲基巴多索隆

甲基巴多索隆性质、用途与生产工艺

生物活性

Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) 是一种IKK抑制剂，具有强的促凋亡和抗炎活性。同时还是有效的Nrf2激活剂和NF-κB抑制剂。Bardoxolone Methyl 可抑制铁死亡。Bardoxolone Methyl 在癌细胞中可诱导凋亡和自噬。

靶点

Target	Value
IKK (Cell-free assay)
Ferroptosis ()
Nrf2 ()
NF-κB ()

体外研究

Bardoxolone Methyl作用于小鼠巨噬细胞，对interferon-Ƴ诱导的一氧化氮的产生具有强效的抑制活性，其IC50 为0.1 nM 。 Bardoxolone Methyl降低白血病HL-60，KG-1和NB4细胞的生存能力，其IC50分别为 0.4，0.4，和0.27μM。 CDDO-ME诱导促凋亡Bax蛋白表达，抑制ERK1 / 2的活化，并且它抑制Bcl-2的磷酸化，这有助于诱导细胞凋亡。 Bardoxolone Methyl可有效地抑制(IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, 和cigarette smoke激活的组成型和可诱导的NF-κB的肿瘤坏死因子。

体内研究

Bardoxolone Methyl(60 mg/kg)体内用药，可减少肺肿瘤的数量，大小和降低严重程度。 Bardoxolone Methyl还可显著降低LPS刺激下的体内炎症因子的反应，诱导脾脏HO-1蛋白表达，对抗致死剂量的LPS保护小鼠。

用途 

CDDO Methyl Ester is a synthetic triterpenoid that inhibits I κBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-reg ulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.

甲基巴多索隆 上下游产品信息

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甲基巴多索隆 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-13324	Bardoxolone methyl		5 mg	312元
2024/04/30	HY-13324	甲基巴多索隆 Bardoxolone methyl	218600-53-4	10 mg	500元

甲基巴多索隆 生产厂家

 

218600-53-4, 甲基巴多索隆 相关搜索:

• Inhibitors
• Inhibitor
• Protein Kinase Inhibitors and Activators
• Pharmaceuticals
• Intermediates & Fine Chemicals
• Apoptosis
• NF-kB
• 天然产物
• 标准品 -中药标准品
• 细胞生物学试剂
• 植物提取物
• 信号转导通路激酶抑制剂
• 抑制剂
• 杂环类
• 小分子抑制剂，天然产物
• 甲基巴多松龙
• 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸
• (4AS,6AR,6BS,8AR,12AS,14AR,14BS)-2,2,6A,6B,9,9,12A-七甲基-10,14-二氧代-11-氰基-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,12A,14,14A,14B-十八氢二萘品苯-4A-甲酸甲酯
• NRF2激活剂(BARDOXOLONE METHYL)
• 甲基巴多索隆, 一种有效的 NRF2 激活剂, 具有抗氧化、抗炎等功效
• 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯 1G
• 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯
• 甲基巴多索隆
• 218600-53-4
• Abametapir Impurity 21
• CDDO Methyl Ester Bardoxolone methyl
• CDDO-Me
• CDDO Methyl Ester
• methyl (4aS,6aR,6bS,8aR,12aS,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate
• Bardoxolone methyl, 98%, a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2)
• Bardoxolone methyl (NSC-713200)
• BARDOXOLONE METHYL; CDDO METHYL ESTER; CDDOME; NSC 713200; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155
• Bardoxolone methyl-13C2 D3 15N
• Bardoxolone methyl USP/EP/BP
• methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylate
• CDDO-Me - Bardoxolone methyl | RTA 402
• methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• CS-322
• (4aS,6aR,6bS,8aR,12aS,14bS)-methyl 11-cyano-2,2,6a
• (4aR,6aR,6bS,8aR,12aR,14bR)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-heptaMethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
• RTA 402
• 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
• Bardoxolone Methyl
• (4aS,6aR,6bS,8aR,12aS,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-he
• BARDOXOLONE METHYL;NSC 713200; RTA 402
• TP-155C
• RTA-402; NSC-713200; TP-155C; METHYL-CDDO; METHYLCDDO;BARDOXOLONE METHYL
• Methyl-CDDO
• MethylCDDO
• (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
• 2-Cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid methyl ester
• Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
• TP-155
• Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester
• Bardoxolone Methyl (RTA 402)
• Bardoxolone Me ester