2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
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- CAS号:
- 177172-49-5
- 英文名:
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- 英文别名:
- R-568;NPS-R568;R 568 hydrochloride;Tecalcet HCl (KRN568;Tecalcet (Hydrochloride);R-568 hydrochloride >=95% (HPLC);2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride;(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride;3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride;Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
- 中文名:
- 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
- 中文别名:
- R-568 盐酸盐;化合物 T13918;2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
- CBNumber:
- CB22518826
- 分子式:
- C18H23Cl2NO
- 分子量:
- 340.28732
- MOL File:
- 177172-49-5.mol
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2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐化学性质
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熔点:
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183.3-184.4 °C
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO : 50 mg/mL (146.93 mM; Need ultrasonic)
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形态:
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Powder
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颜色:
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White to off-white
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2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐性质、用途与生产工艺
Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂，变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。
Tecalcet (NPS 568, 0.1-100 μM) increase [Ca
2+
]i in a concentrationdependent and stereoselective manner.
Tecalcet (NPS 568, 0.1-100 nM) shiftes the concentration-response curve for extracellular Ca
2+
to the left without affecting the maximal response and, thereby, decreases
the EC
50
value for extracellular Ca21 to 0.61±0.04 mM.
Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency.
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Animal Model:
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10-wk-old Male Sprague-Dawley rats weighing 310-350 g.
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Dosage:
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1.5 and 15 mg/kg.
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Administration:
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Orally twice daily for 4 days.
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Result:
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Did not significantly change serum 1,25 (OH)
2
D
3
levels. In contrast, serum PTH levels were reduced by in a dose-dependent manner.
Clearly reduced the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg body wt), and by 50% at a high dose (15 mg/kg body wt), indicating an antiproliferative effect on PT cells.
Reduced PT cell volume in a dose-dependent manner.
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2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-10167A | Tecalcet Hydrochloride | | 1 mg | 335元 |
| 2024/04/30 | HY-10167A | 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
Tecalcet Hydrochloride | 177172-49-5 | 5mg | 1450元 |
2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
生产厂家
177172-49-5, 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐 相关搜索:
- 药靶配体
- R-568 盐酸盐
- 化合物 T13918
- 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
- 177172-49-5
- (R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride
- 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride
- Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
- R-568 hydrochloride >=95% (HPLC)
- NPS-R568
- Tecalcet HCl (KRN568
- R-568
- Tecalcet (Hydrochloride)
- R 568 hydrochloride
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride