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2-클로로-N-[(1R)-1-(3-메톡시페닐)에틸]-벤젠프로판아민염산염 C화학적 특성, 용도, 생산
개요
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR.
용도
Treatment of hyperparathyroidism and related disorders,
such as hypercalcemia (reduction of PTH secretion
through modulation of calcium ion receptors on parathyroid
cells).
상표명
Norcalcin (Amgen).
2-클로로-N-[(1R)-1-(3-메톡시페닐)에틸]-벤젠프로판아민염산염 준비 용품 및 원자재