CINANSERIN HYDROCHLORIDE
|
|
- CAS号:
- 54-84-2
- 英文名:
- CINANSERIN HYDROCHLORIDE
- 英文别名:
- DPTC;maptc;sq10,643;Nsc125717;CINANSERIN;Cinnanserin;DPTC HYDROCHLORIDE;CINANSERIN HYDROCHLORIDE;2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE;DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride
- 中文名:
- CINANSERIN HYDROCHLORIDE
- 中文别名:
- 化合物CINANSERIN HYDROCHLORIDE;N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺盐酸盐
- CBNumber:
- CB2254025
- 分子式:
- C20H25ClN2OS
- 分子量:
- 376.94
- MOL File:
- 54-84-2.mol
|
|
|
CINANSERIN HYDROCHLORIDE化学性质
-
密度:
-
1.22 g/cm3
-
|
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
DMSO : 125 mg/mL (331.62 mM; Need ultrasonic)
-
|
-
形态:
-
Powder
-
|
-
颜色:
-
Light yellow to yellow
-
|
-
水溶解性:
-
Soluble to 50 mM in water
-
|
CINANSERIN HYDROCHLORIDE性质、用途与生产工艺
Cinanserin hydrochloride (SQ 10643) 是一种有效,选择性和高度亲和力的 5-HT2 受体拮抗剂,Ki 为 41 nM。Cinanserin hydrochloride 对 5-HT2 的结合亲和力比对 5-HT1 受体 (Ki 为 3500 nM) 的结合亲和力高得多。Cinanserin hydrochloride 还是严重急性呼吸系统综合症冠状病毒的 3C 样蛋白酶 (3C-like proteinase) 的抑制剂,可大大减少体外的病毒复制。
5-HT
2
Receptor
41 nM (Ki)
|
3C-like proteinase
|
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL
pro
, HCoV-229E 3CL
pro
, with the K
D
values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL
pro
and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL
pro
.
The IC
50
values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL
pro
are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC
50
values for HCoV-229E 3CL
pro
are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C
pro
at concentrations up to 200 μM.
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
Animal Model:
|
Male Wistar rats (250 g) underwent thermal injury
|
Dosage:
|
5 mg/kg
|
Administration:
|
Intravenous injection; for 2 hours
|
Result:
|
Significantly reduced systemic burn edema to shamburn levels..
|
CINANSERIN HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-100943 | Cinanserin hydrochloride | | 5 mg | 1593元 |
2024/04/30 | HY-100943 | CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride | 54-84-2 | 10mg | 2550元 |
CINANSERIN HYDROCHLORIDE
生产厂家
54-84-2, CINANSERIN HYDROCHLORIDE 相关搜索:
- amino
- C20H24N2OSClH
- 化合物CINANSERIN HYDROCHLORIDE
- N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺盐酸盐
- 54-84-2
- edema,replication,Serotonin Receptor,Cinanserin hydrochloride,leukocyte,virus,burn,3C-like,SQ10643,proteinase,endothelial,Influenza Virus,SQ-10643,Cinanserin,Inhibitor,5-hydroxytryptamine Receptor,systemic,5-HT Receptor,inhibit,5-HT2
- N-(2-((3-(Dimethylamino)propyl)thio)phenyl)-3-phenylacrylamide hydrochloride
- (E)-N-[2-[3-(dimethylamino)propylsulfanyl]phenyl]-3-phenylprop-2-enamide
- Nsc125717
- Cinnanserin
- CINANSERIN HYDROCHLORIDE
- CINANSERIN
- DPTC HYDROCHLORIDE
- DPTC
- Cinnamanilide, 2'-[[3-(dimethylamino)propyl]thio]-, monohydrochloride
- 2-Propenamide, N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-, monohydrochloride
- 2'-[[3-(Dimethylamino)propyl]thio]cinnamanilide monohydrochloride
- DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride
- sq10,643
- n-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-2-propenamidmonohyd
- maptc
- 2’-((3-(dimethylamino)propyl)thio)-cinnamanilidmonohydrochloride
- N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE HYDROCHLORIDE
- N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE
- 2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE