CINANSERIN HYDROCHLORIDE
中文名称 | CINANSERIN HYDROCHLORIDE |
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中文同义词 | N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺盐酸盐;化合物CINANSERIN HYDROCHLORIDE |
英文名称 | CINANSERIN HYDROCHLORIDE |
英文同义词 | 2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE HYDROCHLORIDE;2’-((3-(dimethylamino)propyl)thio)-cinnamanilidmonohydrochloride;maptc;n-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-2-propenamidmonohyd;sq10,643;DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride |
CAS号 | 54-84-2 |
分子式 | C20H25ClN2OS |
分子量 | 376.94 |
EINECS号 | |
相关类别 | amino |
Mol文件 | 54-84-2.mol |
结构式 |
CINANSERIN HYDROCHLORIDE 性质
密度 | 1.22 g/cm3 |
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储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | DMSO:125 mg/mL(331.62 mM;需要超声) |
形态 | 粉末 |
颜色 | 浅黄至黄色 |
水溶解性 | Soluble to 50 mM in water |
5-HT 2 Receptor 41 nM (Ki) |
3C-like proteinase
|
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL
pro
, HCoV-229E 3CL
pro
, with the K
D
values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL
pro
and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL
pro
.
The IC
50
values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL
pro
are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC
50
values for HCoV-229E 3CL
pro
are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C
pro
at concentrations up to 200 μM.
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
Animal Model: | Male Wistar rats (250 g) underwent thermal injury |
Dosage: | 5 mg/kg |
Administration: | Intravenous injection; for 2 hours |
Result: | Significantly reduced systemic burn edema to shamburn levels.. |
安全信息
海关编码 | 2921490090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-100943 | Cinanserin hydrochloride | 5 mg | 1593元 | |
2024/04/30 | HY-100943 | CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride | 54-84-2 | 10mg | 2550元 |