CPTH2
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- CAS号:
- 357649-93-5
- 英文名:
- Histone Acetyltransferase Inhibitor IV, CPTH2
- 英文别名:
- CPTH2;Histone Acetyltransferase Inhibitor IV, CPTH2;Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone;Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
- 中文名:
- CPTH2
- 中文别名:
- 4-(4-氯苯基)-2-(2-环戊烯肼基)噻唑;4-(4-氯苯基)-2-(2-环戊基亚基肼基)噻唑;4-(4-氯苯基)-2-(2-环戊烯肼基)噻唑(CPTH2);4-(4-CHLOROPHENYL)-N-(CYCLOPENTYLIDENEAMINO)-1,3-THIAZOL-2-AMINE
- CBNumber:
- CB22602855
- 分子式:
- C14H14ClN3S
- 分子量:
- 291.8
- MOL File:
- 357649-93-5.mol
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CPTH2化学性质
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熔点:
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190-191 °C
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沸点:
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460.3±37.0 °C(Predicted)
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密度:
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1.38±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO
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形态:
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powder
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酸度系数(pKa):
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14.57±0.20(Predicted)
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颜色:
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white to beige
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水溶解性:
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Water: < 0.1 mg/mL (insoluble)
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敏感性:
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Light Sensitive
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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CPTH2性质、用途与生产工艺
CPTH2 是一种有效的 histone acetyltransferase (HAT) 的抑制剂，可调节Gcn5p网络。CPTH2 通过抑制 KAT3B 诱导凋亡并降低ccRCC细胞系的侵袭性。
| Target | Value |
HAT
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Gcn5p
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KAT3B
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CPTH2 (100 μM; 12, 24, 48 hours) causes a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation.
CPTH2 (100 μM; 12 or 48 hours) causes a comparable drop of the activity in both cell lines.
CPTH2 (100 μM; 48 hours) produces a drastic increase in apoptotic/dead cell population after 48 h.
CPTH2 (100 μM; 12, 24, 48 hours) shows a reduced acetylation of both global AcH3 histone and H3AcK18.
CPTH2 (100 μM; 24, 48 hours) is capable to counteract invasion and migration of ccRCC-786-O cells in culture.
CPTH2 (0.2, 0.5, 1 mM) inhibits the growth of a GCN5 deleted strain and a single catalytic mutant E173H.
CPTH2 (0.6, 0.8 mM; for 24 hours) inhibits histone H3 acetylation in yeast cell cultures.
CPTH2 inhibits the Gcn5p dependent functional network.
Cell Proliferation Assay
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Cell Line:
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Papillary thyroid (K1) and clear cell Renal Cell Carcinoma (ccRCC-786-O) cell lines
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Concentration:
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100 μM
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Incubation Time:
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12, 24, 48 hours
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Result:
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Caused a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation.
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Cell Viability Assay
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Cell Line:
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K1 and ccRCC-786-O cell lines
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Concentration:
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100 μM
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Incubation Time:
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24 hours (K1 cell) and 48 hours (ccRCC-786-O cell)
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Result:
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Caused a comparable drop of the activity in both cell lines.
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Apoptosis Analysis
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Cell Line:
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ccRCC-786-O cells
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Concentration:
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100 μM
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Incubation Time:
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48 hours
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Result:
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Produced a drastic increase in apoptotic/dead cell population after 48 h.
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Western Blot Analysis
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Cell Line:
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ccRCC-786-O cells
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Concentration:
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100 μM
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Incubation Time:
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12, 24, 48 hours
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Result:
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Showed a reduced acetylation of both global AcH3 histone and H3AcK18.
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CPTH2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-W013274 | CPTH2 | | 5 mg | 875元 |
| 2024/08/19 | HY-W013274 | CPTH2
CPTH2 | 357649-93-5 | 10mg | 1400元 |
357649-93-5, CPTH2 相关搜索:
- Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
- HAT Inhibitor IV, Gcn5p Inhibitor, CPTH2
- 抑制剂
- 药靶配体
- 合成
- 4-(4-氯苯基)-2-(2-环戊烯肼基)噻唑(CPTH2)
- 4-(4-氯苯基)-2-(2-环戊基亚基肼基)噻唑
- 4-(4-氯苯基)-2-(2-环戊烯肼基)噻唑
- 4-(4-CHLOROPHENYL)-N-(CYCLOPENTYLIDENEAMINO)-1,3-THIAZOL-2-AMINE
- 357649-93-5
- 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
- Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone
- Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
- CPTH2
- Histone Acetyltransferase Inhibitor IV, CPTH2