4-氨基-5-己烯酸盐酸盐
|
|
|
- CAS号:
- 1391054-02-6
- 英文名:
- Vigabatrin (Hydrochloride)
- 英文别名:
- Vigabatrin HCL;Vigabatrin (Hydrochloride);γ-Vinyl-GABA hydrochloride;Aminohexenoic acid (hydrochloride);4-aminohex-5-enoic acid hydrochloride;4-Amino-5-hexenoic acid hydrochloride (1:1);Γ-VINYL-GABA HYDROCHLORIDE;SABRIL HYDROCHLORIDE;Vigabatrin 13C D2 HClQ: What is
Vigabatrin 13C D2 HCl Q: What is the CAS Number of
Vigabatrin 13C D2 HCl Q: What are the applications of
Vigabatrin 13C D2 HCl
- 中文名:
- 4-氨基-5-己烯酸盐酸盐
- 中文别名:
- 盐酸氨己烯酸;氨己烯酸盐酸盐;4-氨基-5-己烯酸盐酸盐;VIGABATRIN(中间体)
- CBNumber:
- CB22624345
- 分子式:
- C6H12ClNO2
- 分子量:
- 165.61798
- MOL File:
- 1391054-02-6.mol
|
|
|
4-氨基-5-己烯酸盐酸盐化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Methanol (Slightly), Water (Slightly)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Off-White to Pale Brown
-
|
-
稳定性:
-
Hygroscopic
-
|
4-氨基-5-己烯酸盐酸盐性质、用途与生产工艺
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride)，一种抑制性神经递质 GABA 乙烯基衍生物，是一种具有口服活性且不可逆的 GABA 转氨酶 (GABA transaminase) 抑制剂。 Vigabatrin hydrochloride 是一种抗癫痫剂，通过抑制 GABA transaminase 对 GABA 的分解代谢来增加脑中 GABA 的水平。
A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.
Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.
4-氨基-5-己烯酸盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-B0033 | Vigabatrin hydrochloride | | 5 mg | 500元 |
| 2024/11/08 | HY-B0033 | 4-氨基-5-己烯酸盐酸盐
Vigabatrin hydrochloride | 1391054-02-6 | 10mg | 800元 |
1391054-02-6, 4-氨基-5-己烯酸盐酸盐 相关搜索:
- Inhibitors
- 抑制剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 氨己烯酸盐酸盐
- VIGABATRIN(中间体)
- 盐酸氨己烯酸
- 4-氨基-5-己烯酸盐酸盐
- 1391054-02-6
- Aminohexenoic acid (hydrochloride)
- γ-Vinyl-GABA hydrochloride
- Vigabatrin 13C D2 HClQ: What is
Vigabatrin 13C D2 HCl Q: What is the CAS Number of
Vigabatrin 13C D2 HCl Q: What are the applications of
Vigabatrin 13C D2 HCl
- Γ-VINYL-GABA HYDROCHLORIDE;SABRIL HYDROCHLORIDE
- 4-aminohex-5-enoic acid hydrochloride
- 4-Amino-5-hexenoic acid hydrochloride (1:1)
- Vigabatrin HCL
- Vigabatrin (Hydrochloride)